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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPK3
All Species:
50
Human Site:
S225
Identified Species:
78.57
UniProt:
P27361
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P27361
NP_001035145.1
379
43136
S225
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Chimpanzee
Pan troglodytes
XP_510921
379
43006
S225
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_854045
378
42847
S224
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Cat
Felis silvestris
Mouse
Mus musculus
Q63844
380
43048
S226
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Rat
Rattus norvegicus
P21708
380
43062
S226
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989481
368
41924
S216
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Frog
Xenopus laevis
P26696
361
41238
S211
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Zebra Danio
Brachydanio rerio
NP_958915
392
44081
S239
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P40417
426
49103
S271
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Honey Bee
Apis mellifera
XP_393029
371
42705
S210
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Nematode Worm
Caenorhab. elegans
P39745
444
50644
S279
N
S
K
G
Y
T
K
S
I
D
V
W
S
V
G
Sea Urchin
Strong. purpuratus
NP_999813
369
42176
S214
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39024
376
42833
A224
N
C
S
E
Y
T
A
A
I
D
I
W
S
V
G
Baker's Yeast
Sacchar. cerevisiae
P16892
353
40754
M204
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
Red Bread Mold
Neurospora crassa
Q96TL5
358
41225
E194
T
W
Q
K
Y
D
V
E
V
D
I
W
S
A
G
Conservation
Percent
Protein Identity:
100
95.7
N.A.
96.3
N.A.
96.8
97.1
N.A.
N.A.
83.1
82.3
82.4
N.A.
68.5
78.3
62.1
77.5
Protein Similarity:
100
96.8
N.A.
97.6
N.A.
97.1
97.3
N.A.
N.A.
88.3
87.5
87.2
N.A.
75.5
84.4
72.5
84.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
100
100
93.3
100
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
100
100
100
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
48.5
47.2
46.1
Protein Similarity:
N.A.
N.A.
N.A.
66.7
63.8
62.5
P-Site Identity:
N.A.
N.A.
N.A.
66.6
6.6
40
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
20
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
14
7
0
0
0
0
0
7
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
7
% C
% Asp:
0
0
0
0
0
7
0
0
7
94
0
0
0
0
0
% D
% Glu:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
80
0
0
0
0
0
0
0
0
0
7
94
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
87
0
87
0
0
0
0
% I
% Lys:
0
0
87
7
0
0
80
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
87
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% R
% Ser:
7
80
7
0
7
0
0
80
0
0
0
7
94
0
0
% S
% Thr:
7
0
0
0
0
87
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
7
0
7
7
7
0
0
87
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
7
94
0
0
0
% W
% Tyr:
0
0
0
7
94
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _